RANKL多克隆抗體
| 貨號 | 品牌 | CAS | 規(guī)格 | 銷售價(RMB) | 折扣價(RMB) | 備注 | 數(shù)量 |
| ABP0140-100μL | Abbkine | 無 | 100μL | 1998 | 1998 | 無 |
商品信息
| 產(chǎn)品英文名稱 | RANKL Polyclonal Antibody |
| 免疫原 | 合成多肽：人源蛋白的C末端，RANKL |
| 宿主 | 兔 |
| 反應(yīng)性 | 人, 大鼠, 小鼠 |
| 應(yīng)用 | ELISA, IHC-P, WB |
| 實驗建議 | 最佳的工作稀釋比例需要客戶摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:500-1:2000，IHC-P：1:100-1:300，ELISA：1:20000。 |
| 克隆性 | 多克隆 |
| 純化工藝 | 使用表位特異性的免疫原，通過親和層析，從兔抗血清中親和純化抗體。 |
商品屬性
| 產(chǎn)品形式 | 液體溶液 |
| 濃度 | 1 mg/ml |
| 分子量 | 35 KD |
| 儲存緩沖液 | PBS緩沖液（pH 7.4），含有0.5%BSA（穩(wěn)定劑），0.02％疊氮化鈉（防腐劑）和50％甘油。 |
| 保存建議 | 自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為最大限度的避免損失，請在打開管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。 |
| 運輸條件 | 藍(lán)冰運輸 |
| 警告 | 本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何專利或許可證。對于使用本產(chǎn)品可能發(fā)生的專利侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。 |
附加信息
| 背景 | TNFSF11 encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. Tumor necrosis factor ligand superfamily member 11 was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
| 基因ID | 8600 |
| 別名 | TNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGLReceptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254 |
| 其它 | 該抗體可檢測內(nèi)源蛋白 |
| 蛋白質(zhì)ID | O14788 |
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